Senior Director, DMPK

Department: DMPK / Toxicology

Location: South San Francisco, California, United States

Summary:  We are seeking an experienced, creative, and highly motivated expert with industry research experience in DMPK focused on small molecule lead optimization for discovery research programs, preclinical and clinical drug development. This position will be responsible for leading DMPK interactions with discovery research and partnering with Biologists and Medicinal chemists to facilitate the successful achievement of lead optimization programs and the rapid and efficient progression of drug candidates in preclinical development.

Key Responsibilities include:

  • Lead overall scientific, technical, and operational efforts supporting DMPK across the project portfolio
  • Supervise and mentor DMPK scientists supporting multiple drug discovery and clinical programs
  • Management of external CROs to support Research objectives
  • Provide scientific guidance on chemical lead optimization programs and work in close collaboration with Medicinal Chemists and Biologists to optimize the DMPK properties of candidate drugs
  • Provide preclinical support and evaluation of drug candidates in development programs
  • Close interaction with individual research and development groups, and effective communication with Assembly R&D leadership

 Preferred Qualifications include:

  • PhD or equivalent degree in Chemistry, Biochemistry or related discipline, combined with 13+ years of pharmaceutical industry experience and a strong background in ADME and pharmacokinetics/pharmacodynamics as applied in small molecule lead optimization
  • Demonstrated technical knowledge and industrial experience in multiple DMPK areas and an in depth understanding of the experimental DMPK methodologies and approaches, in vitro and in vivo, utilized in chemical lead optimization
  • The ability to work with multiple disciplines in drug discovery and provide exceptional guidance to medicinal chemists and Biologists in the lead optimization process.
  • The ability to conduct innovative research in DMPK applied to the discovery of novel drug candidates to achieve defined milestones in a fast paced environment 
  • Extensive knowledge of preclinical drug development and in the preparation of regulatory documents, e.g. INDs and NDAs. In addition, she/he should be a goal-oriented and effective leader. Additional requirements include effective mentoring of scientific staff and highly effective organizational and communication skills
  • The candidate should be self-motivated, with a track record of productivity, demonstrated leadership potential, possess effective interpersonal skills and be team oriented.

About Assembly Bio

Assembly Biosciences (NASDAQ: ASMB) is an ambitious clinical stage biopharmaceutical company with cutting-edge therapeutics potentially capable of improving the lives of millions living with chronic hepatitis B virus (HBV) infection around the world.  We are currently focused on an HBV program intent on creating a new class of oral therapeutics to finally cure hepatitis B.  Our program is built on ingenuity, vision and experience and has the potential to improve cure rates for individuals with chronic hepatitis B (HBV) in our lifetime. Our strong scientific expertise in discovering small molecules targeting the HBV core protein has made us a leader in the field. 

We pride ourselves on creating a culture and work environment that is scientifically driven, ambitious, and collaborative.  We encourage diversity of thought that leads to great innovation and are looking to add great people to our dynamic team who are driven to transform the lives of patients.  We set our sights high—and pursue our goals with determination. Our unique organization stands ready to welcome talented, motivated individuals, who share our ambitions.

EEO Statement

Assembly Biosciences is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. We are committed to the principle of equal employment opportunity for all employees and to providing employees with a work environment free of discrimination and harassment. All employment decisions are based on business needs, job requirements and individual qualifications, without regard to race, color, religion or belief, national, social or ethnic origin, sex (including pregnancy), age, physical, mental or sensory disability, HIV status, sexual orientation, gender identity and/or expression, marital, civil union or domestic partnership status, past or present military service, family medical history or genetic information, family or parental status, or any other status protected by the laws or regulations in the locations where we operate. We will not tolerate discrimination or harassment based on any of these characteristics.


Apply for this Job

* - required fields





Attach File or Paste

Attach File or Paste







U.S. Equal Opportunity Employment Information (Completion is voluntary)

Individuals seeking employment at this company are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation. You are being given the opportunity to provide the following information in order to help us comply with federal and state Equal Employment Opportunity/Affirmative Action record keeping, reporting, and other legal requirements.

Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.



If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.


Why are you being asked to complete this form?

Because we do business with the government, we must reach out to, hire, and provide equal opportunity to qualified people with disabilities1. To help us measure how well we are doing, we are asking you to tell us if you have a disability or if you ever had a disability. Completing this form is voluntary, but we hope that you will choose to fill it out. If you are applying for a job, any answer you give will be kept private and will not be used against you in any way.

If you already work for us, your answer will not be used against you in any way. Because a person may become disabled at any time, we are required to ask all of our employees to update their information every five years. You may voluntarily self-identify as having a disability on this form without fear of any punishment because you did not identify as having a disability earlier.

How do I know if I have a disability?

You are considered to have a disability if you have a physical or mental impairment or medical condition that substantially limits a major life activity, or if you have a history or record of such an impairment or medical condition.

Disabilities include, but are not limited to:

  • Blindness
  • Deafness
  • Cancer
  • Diabetes
  • Epilepsy
  • Autism
  • Cerebral palsy
  • HIV/AIDS
  • Schizophrenia
  • Muscular dystrophy
  • Bipolar disorder
  • Major depression
  • Multiple sclerosis (MS)
  • Missing limbs or partially missing limbs
  • Post-traumatic stress disorder (PTSD)
  • Obsessive compulsive disorder
  • Impairments requiring the use of a wheelchair
  • Intellectual disability (previously called mental retardation)

Reasonable Accommodation Notice

Federal law requires employers to provide reasonable accommodation to qualified individuals with disabilities. Please tell us if you require a reasonable accommodation to apply for a job or to perform your job. Examples of reasonable accommodation include making a change to the application process or work procedures, providing documents in an alternate format, using a sign language interpreter, or using specialized equipment.

1Section 503 of the Rehabilitation Act of 1973, as amended. For more information about this form or the equal employment obligations of Federal contractors, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.



BACK | NEXT