Scientist I, Biology (Microbiome)
Location: South San Francisco, California, United States
The Scientist I, Biology will have industry experience and deep expertise in immunology, mucosal and in vivo Biology. As a key member of the research biology group, the scientist will work collaboratively with cross-functional R&D teams and will bring strong bench capabilities with in vitro and in vivo immunology models. The ideal candidate will have demonstrated experience with multiple facets of in vitro assays and relevant animal models, strong interpersonal skills and enjoy creatively solving problems in a team environment.
Key Responsibilities include:
- Design and conduct state-of-the art laboratory experiments using cell-based assays and in vivo disease models with cellular & molecular analytical tools
- Develop and implement discovery methodologies for identification of PD/biomarkers and PK/PD activities for candidate therapeutics
- Analyze and interpret data, prepare reports and present results at internal team meetings and to senior management
- Contribute technical expertise and scientific insights from immunology, mucosal biology and disease physiology to experimental strategies
Preferred Qualifications include:
- PhD in immunology, cell biology, cancer biology or biology with 2 years of postdoctoral and/or relevant industry experience
- Strong knowledge of immunology and/or mucosal biology, and direct experience in at least one major human therapeutic: e.g. immuno-oncology, inflammation, autoimmunity or other
- Experience with preclinical drug discovery and target discovery & validation
- Evidence of independent and rigorous scientific capabilities and accomplishments, including publications and presentations at conferences; must be able to deliver high-quality research results on timelines
- Demonstrated ability to be proactive, innovative and creative in solving critical path research problems
- Hands-on expertise with in vitro assays using primary cells and cell lines and in vivo animal efficacy models used for inflammation, autoimmunity, immuno-oncology or other relevant diseases. Experience with flow cytometry-based immune cell phenotyping of in vivo samples preferred
- Proven ability to design, coordinate and oversee in vivo studies with external CROs and collaborators
- Experience with in vivo pharmacology assessments in a discovery research context preferred
- Strong expertise with primary cell and tissue isolation methodologies and experience with histology and immunohistochemistry preferred
- Expertise in data analysis and presentation software: MS PowerPoint, Word, Excel, GraphPad Prism
- Excellent communication, oral presentation and written skills
- Excellent organizational and time management skills with high attention to detail
- Collaborative, enthusiastic and motivated individual who can swiftly change priorities in a fast-paced and team-oriented environment
- Goal-oriented and with the ability to deliver on timelines and commitments
About Assembly Bio
Assembly Biosciences (NASDAQ: ASMB) is a clinical-stage biotechnology company developing innovative therapeutics targeting hepatitis B virus (HBV) and diseases associated with the microbiome. The HBV program is focused on advancing a new class of potent, oral core inhibitors that have the potential to increase cure rates for chronically infected patients. The microbiome program is developing novel oral live microbial biotherapeutic candidates with Assembly Bio’s fully integrated platform, including a robust process for strain identification and selection, GMP banking and production, and targeted delivery to the lower gastrointestinal tract with the GEMICEL® technology.
We believe our Microbiome platform represents a best in class approach to developing biopharmaceutical agents from live biotherapeutic products. ABI-M201, our lead program in mildly to moderately active ulcerative colitis (UC), is currently in a phase 1b clinical trial. This program is part of a broader collaboration we established with Allergan in 2017 for gastrointestinal programs such as UC, Crohn’s disease and Irritable Bowel Syndromes. Our internal pipeline comprises first in class or best in class live microbial biotherapeutic approaches in areas such as oncology, immune mediated and metabolic disorders, and other areas of high medical need.
We pride ourselves on creating a culture and work environment that is scientifically driven, ambitious, and collaborative. We encourage diversity of thought that leads to great innovation and are looking to add to our dynamic team of great people who are driven to transform the lives of patients.
Assembly Bio is headquartered in Carmel, Indiana, while the R&D headquarters is in South San Francisco. The Company also has a microbiome manufacturing facility in Groton, CT, and offices in China. Assembly Bio has a strong balance sheet having raised approximately $166 million in July 2018. We are positioned well to build the next phase of the Company toward global development and commercialization of our innovative medicines in HBV-cure and the Microbiome.
Assembly Biosciences is an Equal Opportunity Employer and prohibits discrimination and harassment of any kind. We are committed to the principle of equal employment opportunity for all employees and to providing employees with a work environment free of discrimination and harassment. All employment decisions are based on business needs, job requirements and individual qualifications, without regard to race, color, religion or belief, national, social or ethnic origin, sex (including pregnancy), age, physical, mental or sensory disability, HIV status, sexual orientation, gender identity and/or expression, marital, civil union or domestic partnership status, past or present military service, family medical history or genetic information, family or parental status, or any other status protected by the laws or regulations in the locations where we operate. We will not tolerate discrimination or harassment based on any of these characteristics.
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